Substituted 3-Benzylcoumarins as Allosteric MEK1 Inhibitors: Design, Synthesis and Biological Evaluation as Antiviral Agents

In order to find novel antiviral agents, a series of allosteric MEK1 inhibitors were designed and synthesized.Based on docking results, multiple optimizations were made on the coumarin scaffold.Some of the derivatives showed excellent MEK1 binding affinity Dual Inlet 3 way Water Valve in the appropriate enzymatic assays and displayed obvious inhibi

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